Christe M, Gattlen P, Fritschi J, Lämmle B, Berger W, Marbet G A, Duckert F
Thromb Haemost. 1984 Dec 29;52(3):221-3.
The contact phase has been studied in diabetics and patients with macroangiopathy. Factor XII and high molecular weight kininogen (HMWK) are normal. C1-inhibitor and also alpha 2-macroglobulin are significantly elevated in diabetics with complications, for alpha 2-macroglobulin especially in patients with nephropathy, 137.5% +/- 36.0 (p less than 0.001). C1-inhibitor is also increased in vasculopathy without diabetes 113.2 +/- 22.1 (p less than 0.01). Prekallikrein (PK) is increased in all patients' groups (Table 2) as compared to normals. PK is particularly high (134% +/- 32) in 5 diabetics without macroangiopathy but with sensomotor neuropathy. This difference is remarkable because of the older age of diabetics and the negative correlation of PK with age in normals.
已经对糖尿病患者和患有大血管病变的患者的接触相进行了研究。因子 XII 和高分子量激肽原（HMWK）正常。在有并发症的糖尿病患者中，C1 抑制剂以及α2-巨球蛋白显著升高，对于α2-巨球蛋白，尤其是在肾病患者中，为 137.5%±36.0（p＜0.001）。在无糖尿病的血管病变患者中，C1 抑制剂也升高，为 113.2±22.1（p＜0.01）。与正常对照组相比，所有患者组中的前激肽释放酶（PK）均升高（表 2）。在 5 例无大血管病变但有感觉运动神经病变的糖尿病患者中，PK 特别高（134%±32）。由于糖尿病患者年龄较大以及正常对照组中 PK 与年龄呈负相关，所以这种差异很显著。
