Neighbour P A
Ann N Y Acad Sci. 1984;436:181-91. doi: 10.1111/j.1749-6632.1984.tb14789.x.
Peripheral blood lymphocytes from patients with multiple sclerosis (MS) have been shown by numerous investigators to function abnormally in a variety of immunological tests in vitro. In this article, data concerning defective natural killer (NK) cell function and interferon production by MS patients' lymphocytes have been reviewed. Production of IFN-alpha and IFN-gamma by appropriately stimulated lymphocytes has been shown to be significantly reduced in many patients with acute remitting or chronic progressive disease. Furthermore, a significant proportion of these patients has been found to exhibit reduced levels of endogenous and augmented NK cell activity. A likely explanation for these phenomena is that altered traffic occurring as a consequence of disease has led to a relative loss of NK and IFN-producing cells from the peripheral circulation. Flow cytometric data obtained using monoclonal antibodies that selectively label these effector populations were presented. Possible explanations for the observed defects and their significance relative to our understanding of the etiopathogenesis of MS were discussed.
众多研究者已表明，多发性硬化症（MS）患者的外周血淋巴细胞在多种体外免疫测试中功能异常。在本文中，已对有关MS患者淋巴细胞自然杀伤（NK）细胞功能缺陷和干扰素产生的数据进行了综述。在许多急性缓解型或慢性进展型疾病患者中，经适当刺激的淋巴细胞产生的IFN-α和IFN-γ已被证明显著减少。此外，已发现这些患者中有很大一部分内源性NK细胞活性降低而增强性NK细胞活性也降低。对这些现象的一个可能解释是，疾病导致的交通改变已导致外周循环中NK细胞和产生干扰素的细胞相对丢失。展示了使用选择性标记这些效应细胞群体的单克隆抗体获得的流式细胞术数据。讨论了观察到的缺陷的可能解释及其相对于我们对MS病因发病机制理解的意义。
