Kondoh M, Ohe M, Ono A, Hagihira H
J Nutr Sci Vitaminol (Tokyo). 1984 Dec;30(6):569-76. doi: 10.3177/jnsv.30.569.
Intragastric administration of casein, oleic acid, or polyvinylpyrrolidone resulted in a marked increase in the pancreatic secretion of enzymes, and the administration of 0.03% sodium saccharin, at the concentration permitted in soft drinks, inhibited this increase with these substances. The stimulation of secretion of pancreatic juice-bile mixture by these substances was also inhibited by administration of sodium saccharin. Intravenous injection of CCK-PZ (cholecystokinin-pancreozymin) during inhibition by sodium saccharin, caused a rapid increase in amylase output, suggesting that sodium saccharin acts on the site(s) of CCK-PZ release to prevent its secretion even in the presence of a stimulant, but does not reduce the sensitivity of the pancreas to CCK-PZ. Sodium saccharin seemed to have an effect on secretin release similar to that on CCK-PZ release, judging from the results for the volume of juice-bile mixture.
胃内给予酪蛋白、油酸或聚乙烯吡咯烷酮会导致胰腺酶分泌显著增加，而给予软饮料中允许浓度的0.03%糖精钠可抑制这些物质引起的这种增加。糖精钠的给药也抑制了这些物质对胰液 - 胆汁混合物分泌的刺激。在糖精钠抑制期间静脉注射胆囊收缩素 - 促胰酶素（CCK - PZ），会导致淀粉酶输出迅速增加，这表明糖精钠作用于CCK - PZ的释放部位，即使在存在刺激物的情况下也能阻止其分泌，但不会降低胰腺对CCK - PZ的敏感性。从胰液 - 胆汁混合物的体积结果判断，糖精钠似乎对促胰液素释放有类似于对CCK - PZ释放的作用。
