Fritschka E, Distler A, Gotzen R, Thiede H M, Philipp T
J Cardiovasc Pharmacol. 1984;6 Suppl 7:S1100-4.
The antihypertensive effect of nitrendipine (2 X 10 to 2 X 20 mg/day) was compared with that of propranolol (2 X 80 to 2 X 160 mg/day) in a randomized crossover study. Twenty-five patients were treated over two 4-week periods following a placebo period of 2 weeks. Three patients dropped out of the study because of side-effects (two on nitrendipine and one on propranolol). Arterial pressures decreased in a comparable manner from 171/107 mm Hg (measured in a sitting position) to 147/91 mm Hg after 4 weeks on nitrendipine and to 145/93 mm Hg after 4 weeks on propranolol. The frequency of side-effects possibly related to treatment was comparable for both drugs, but decreased with the duration of therapy with nitrendipine only. The antihypertensive effect of nitrendipine, but not of propranolol, correlated positively with age and plasma noradrenaline.
在一项随机交叉研究中，比较了尼群地平（每日2×10至2×20毫克）与普萘洛尔（每日2×80至2×160毫克）的降压效果。在经过2周的安慰剂期后，25名患者在两个4周疗程中接受治疗。3名患者因副作用退出研究（2名服用尼群地平，1名服用普萘洛尔）。服用尼群地平4周后，动脉血压以类似方式从（坐姿测量）171/107毫米汞柱降至147/91毫米汞柱，服用普萘洛尔4周后降至145/93毫米汞柱。两种药物可能与治疗相关的副作用发生率相当，但仅尼群地平的副作用随治疗持续时间而减少。尼群地平的降压效果与年龄和血浆去甲肾上腺素呈正相关，而普萘洛尔则不然。
