多糖与硅及硅橡胶表面的共价偶联。

Covalent coupling of polysaccharides to silicon and silicon rubber surfaces.

作者信息

Elam J H, Nygren H, Stenberg M

出版信息

J Biomed Mater Res. 1984 Oct;18(8):953-9. doi: 10.1002/jbm.820180809.

DOI:10.1002/jbm.820180809

Abstract

A method to produce a hydrogel by covalently coupling dextran polysaccharide to silicon and silicon rubber surfaces is described. A bifunctional epoxysilane was used as coupling mediator and the conditions for the reaction were optimized. Coupling of the silane to silicon rubber was possible only after oxidation of the surface by plasma etching. The reaction between the epoxy-group and dextran was concentration dependent and required high concentrations of dextran. The turnover rate of fibrinogen in solution at the hydrophilic surface was found to be high when measured by ellipsometry.

摘要

描述了一种通过将葡聚糖多糖共价偶联到硅和硅橡胶表面来制备水凝胶的方法。使用双功能环氧硅烷作为偶联介质，并对反应条件进行了优化。只有在通过等离子体蚀刻对表面进行氧化后，硅烷才能与硅橡胶偶联。环氧基团与葡聚糖之间的反应取决于浓度，并且需要高浓度的葡聚糖。通过椭偏仪测量发现，在亲水性表面的溶液中纤维蛋白原的周转速率很高。