Biswas N M, Paul B
Gegenbaurs Morphol Jahrb. 1977;123(5):759-63.
The enzymes delta5-3beta-hydroxysteroid dehydrogenase delta5-3beta-HSD) and glucose-6-phosphate dehydrogenase (G-6-PDH) were demonstrated histochemically in the adrenal cortex of female rat. The activities of these enzymes were increased significantly in the alloxan-treated rats kept in LD (light: darkness) cycles of 10:14 h. Continuous light exposure to diabetic animals appeared to decrease delta5-3beta-HSD and g-6-PDH in comparison to the diabetic rats kept in 10 h illumination. The evidence indicates that suppression of adrenal steroidogenesis in diabetic rats after exposure to continuous light is due to the alteration of pentose phosphate pathway.
在雌性大鼠的肾上腺皮质中，通过组织化学方法证实了δ5-3β-羟基类固醇脱氢酶（δ5-3β-HSD）和葡萄糖-6-磷酸脱氢酶（G-6-PDH）的存在。在光照:黑暗周期为10:14小时的条件下饲养的四氧嘧啶处理大鼠中，这些酶的活性显著增加。与在10小时光照条件下饲养的糖尿病大鼠相比，持续光照的糖尿病动物中δ5-3β-HSD和G-6-PDH似乎减少。有证据表明，持续光照后糖尿病大鼠肾上腺类固醇生成的抑制是由于磷酸戊糖途径的改变。
