硫胺素焦磷酸处理后大鼠的磷酸戊糖途径与睾丸类固醇生成
Pentose phosphate pathway and testicular steroidogenesis in rats following oxythiamine treatment.
作者信息
Deb C, Mukherjee R, Kaul P, Mallick N
出版信息
Endokrinologie. 1977 Jul;69(2):143-50.
Suppression of delta5-3beta-hydroxy steroid dehydrogenase (delta5-3beta-OHD) and glucose-6-phosphate dehydrogenase (G-6-P-D) activities along with concomitant stimulation of succinic dehydrogenase (SDH) activity were observed in the rat testicular tissues following treatment with oxythiamine HC1, an inhibitor of pentose phosphate pathway. The same treatment also resulted in an accumulation of cholesterol and ascorbic acid in the gland associated with a decrease in the weights of seminal vesicle and prostate. The results suggest a diminution in testicular steroid biogenesis following an alteration of pentose phosphate pathway.
在用戊糖磷酸途径抑制剂盐酸氧硫胺处理大鼠睾丸组织后，观察到δ5-3β-羟基类固醇脱氢酶（δ5-3β-OHD）和葡萄糖-6-磷酸脱氢酶（G-6-P-D）的活性受到抑制，同时琥珀酸脱氢酶（SDH）的活性受到刺激。相同处理还导致腺体中胆固醇和抗坏血酸的积累，同时精囊和前列腺重量减轻。结果表明，戊糖磷酸途径改变后，睾丸类固醇生物合成减少。
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