脂质体电荷对针对灭活脑心肌炎病毒和塞姆利基森林病毒的中和抗体反应的影响。
The effect of liposomal charge on the neutralizing antibody response against inactivated encephalomyocarditis and Semliki Forest viruses.
作者信息
Kraaijeveld C A, Schilham M, Jansen J, Benaissa-Trouw B, Harmsen M, van Houte A J, Snippe H
出版信息
Clin Exp Immunol. 1984 Jun;56(3):509-14.
Abstract
The primary neutralizing antibody response to encephalomyocarditis (EMC) virus and Semliki Forest virus (SFV) is enhanced by addition of either negatively or positively charged liposomes. The purified u.v. light inactivated viruses were merely mixed with liposomes and injected intraperitoneally (i.p.) into mice. In contrast, neutral liposomes were unable to enhance the primary response to these viruses. Furthermore primary immunization with inactivated SFV mixed with either neutral, positively or negatively charged liposomes was associated with an enhancement of the secondary humoral response after i.p. booster injection of mice with inactivated virus alone. But neutral liposomes seemed to be less effective in this respect than either positively or negatively charged liposomes.
摘要
通过添加带负电荷或正电荷的脂质体，可增强对脑心肌炎（EMC）病毒和Semliki森林病毒（SFV）的主要中和抗体反应。纯化的经紫外线灭活的病毒仅与脂质体混合，然后腹腔内（i.p.）注射到小鼠体内。相比之下，中性脂质体无法增强对这些病毒的主要反应。此外，用与中性、带正电荷或带负电荷的脂质体混合的灭活SFV进行初次免疫，与仅用灭活病毒对小鼠进行腹腔加强注射后的二次体液反应增强有关。但在这方面，中性脂质体似乎比带正电荷或带负电荷的脂质体效果要差。
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