Leitch A G
Clin Sci (Lond). 1984 Aug;67(2):153-9. doi: 10.1042/cs0670153.
The history, biosynthetic pathways and biological activities of the leukotrienes have been reviewed. These extremely potent substances probably play a major role in the manifestations of reversible obstructive airways disease and possibly in other diseases of the lung. Their relative contribution remains to be determined and awaits the development of an antagonist or 5-lipoxygenase inhibitor which can be safely administered to man. Perhaps in man in vivo, as has been shown in vitro with human airways tissues [100], the combination of an antihistamine and a leukotriene antagonist will prevent antigen-induced and possibly other forms of airways smooth muscle constriction.
白三烯的历史、生物合成途径及生物活性已被综述。这些极具效力的物质可能在可逆性阻塞性气道疾病的表现中起主要作用，并且可能在其他肺部疾病中也起作用。它们的相对贡献仍有待确定，这有待开发出一种能安全用于人体的拮抗剂或5-脂氧合酶抑制剂。或许在人体体内，正如在人体气道组织的体外实验中所显示的那样[100]，抗组胺药和白三烯拮抗剂联合使用将预防抗原诱导的以及可能其他形式的气道平滑肌收缩。
