Leitch A G
Ann Acad Med Singap. 1985 Jul;14(3):503-7.
Recent advances in biochemistry and cell biology have allowed the determination of the structure and biosynthetic pathways of the leukotriene constituents of slow-reacting substance of anaphylaxis. The sulphidopeptide leukotrienes have potent biological actions including effects on smooth muscle, mucus secretion and vascular permeability whereas leukotriene B3 is a powerful chemoattractant for neutrophils. It seems likely that the biological activities of the leukotrienes make a substantial contribution to the pathogenesis of asthma and that research directed towards the development of antagonists or inhibitors of leukotriene synthesis may lead to a major therapeutic advance.
生物化学和细胞生物学领域的最新进展已使人们能够确定过敏反应慢反应物质中白三烯成分的结构和生物合成途径。含硫肽白三烯具有强大的生物学活性，包括对平滑肌、黏液分泌和血管通透性的影响，而白三烯B3是中性粒细胞的一种强力趋化剂。白三烯的生物学活性似乎对哮喘的发病机制有重大影响，针对开发白三烯合成拮抗剂或抑制剂的研究可能会带来重大的治疗进展。
