Lewiński A, Sewerynek E, Konopacki J, Pawlikowski M, Lewińska M K, Smith N K, Reiter R J
Endocr Res. 1984;10(1):49-61. doi: 10.1080/07435808409046765.
Effects of intraventricular injections of 6-hydroxydopamine (6-OHDA) on adrenocortical cell proliferation in rats have been investigated by means of the colchicine metaphase-arrest technique. In the group of animals receiving 6-OHDA alone, an increase of mean mitotic activity rate (MMAR) was observed at 96 h and 144 h after injection. This rise of MMAR was completely inhibited by pretreatment of animals with desmethylimipramine (DMI) - a blocker of norepinephrine uptake. It is concluded that enhancement of ACTH secretion is responsible for the above mentioned increase of mitotic activity after 6-OHDA administration. This phenomenon is related to abolition of the inhibitory noradrenergic effect on ACTH secretion by 6-OHDA treatment. Additionally, the results suggest little or no involvement of dopaminergic neurons in early changes of ACTH secretion after intraventricular 6-OHDA.
已通过秋水仙素中期阻断技术研究了脑室内注射6-羟基多巴胺（6-OHDA）对大鼠肾上腺皮质细胞增殖的影响。在仅接受6-OHDA的动物组中，注射后96小时和144小时观察到平均有丝分裂活性率（MMAR）增加。用去甲丙咪嗪（DMI）——一种去甲肾上腺素摄取阻滞剂对动物进行预处理，可完全抑制MMAR的这种升高。得出的结论是，促肾上腺皮质激素（ACTH）分泌的增强是6-OHDA给药后上述有丝分裂活性增加的原因。这种现象与6-OHDA处理消除对ACTH分泌的抑制性去甲肾上腺素能作用有关。此外，结果表明多巴胺能神经元在脑室内注射6-OHDA后ACTH分泌的早期变化中几乎没有或没有参与。
