Lewiński A, Konopacki J, Pawlikowski M, Lewińska M K, Smith N K, Reiter R J
Anat Rec. 1984 Mar;208(3):421-6. doi: 10.1002/ar.1092080312.
Effects of intraventricular injections of 6-hydroxydopamine (6-OHDA; 200 micrograms/20 microliter vehicle) on anterior pituitary cell proliferation in rats have been investigated by means of the colchicine metaphase-arrest technique. In those groups of animals receiving 6-OHDA alone or 6-OHDA plus desmethylimipramine (DMI, 25 mg/kg body weight i.p.), where the mean mitotic activity rates (MMARs) were initially low at 48 hours, an increase of MMARs was observed at 96 and 144 hours after the drug injections. At 144 hours after drug administration, the MMARs values in the 6-OHDA-injected group and in the 6-OHDA + DMI-treated group were significantly higher than those in the control groups. This increase of MMARs resulted from the enhancement of acidophilic and chromophobe cell proliferation. The low MMARs at 48 hours after 6-OHDA injection are probably a result of dopamine release from damaged nerve endings; the enhancement of MMARs (particularly evident in the 6-OHDA + DMI-treated group) at 96 and 144 hours after drug administration is presumably related to a deficiency of dopaminergic control of anterior pituitary cell proliferation.
已通过秋水仙碱中期阻断技术研究了脑室内注射6-羟基多巴胺（6-OHDA；200微克/20微升溶媒）对大鼠垂体前叶细胞增殖的影响。在那些单独接受6-OHDA或接受6-OHDA加去甲丙咪嗪（DMI，25毫克/千克体重腹腔注射）的动物组中，其平均有丝分裂活性率（MMARs）在48小时时最初较低，但在药物注射后96小时和144小时观察到MMARs增加。在给药后144小时，注射6-OHDA的组和6-OHDA + DMI治疗组的MMARs值显著高于对照组。MMARs的这种增加是由于嗜酸性细胞和嫌色细胞增殖增强所致。6-OHDA注射后48小时MMARs较低可能是受损神经末梢释放多巴胺的结果；给药后96小时和144小时MMARs的增加（在6-OHDA + DMI治疗组中尤为明显）大概与垂体前叶细胞增殖的多巴胺能控制不足有关。
