Hostetler K Y
Fed Proc. 1984 Aug;43(11):2582-5.
More than 30 cationic amphiphilic drugs have been shown to cause phospholipidosis in humans, animals, and cultured cells. Evidence obtained with drug-treated rats and cultured Madin-Darby canine kidney cells grown in the presence of these agents suggests a three-step mechanism: 1) the agents enter the target cell readily: 2) they concentrate in cell lysosomes; and 3) they inhibit lysosomal phospholipases A and C. The inhibition may be direct, or it may be indirect resulting from effects on lysosomal pH. This mechanism may also be relevant to other cells and tissues, although the evidence to date has been obtained in only liver and MDCK cells.
已有超过30种阳离子两亲性药物被证明可在人类、动物和培养细胞中引起磷脂蓄积症。在这些药物存在的情况下，用药物处理的大鼠以及培养的麦迪逊-达比犬肾细胞所获得的证据提示了一种三步机制：1）这些药物很容易进入靶细胞；2）它们在细胞溶酶体中蓄积；3）它们抑制溶酶体磷脂酶A和C。这种抑制可能是直接的，也可能是由于对溶酶体pH值的影响而间接产生的。尽管迄今为止仅在肝脏和MDCK细胞中获得了证据，但这种机制可能也与其他细胞和组织有关。
