Thomsen L L, Roberton A M, Wong J, Lee S P, Tasman-Jones C
Digestion. 1984;29(3):129-37. doi: 10.1159/000199022.
When Dark Agouti rats were changed from a conventional pellet diet containing 3.3% crude fibre and 4% fat to the experimental diet containing 5% pectin and 17% fat, the levels of n-butyrate in the caecum rapidly decreased more than fivefold. Such a change could be important as n-butyrate is known to be a major energy source for colonocytes, and to affect colon tumour cell development in vitro. Striking decreases in the caecal concentrations of the short chain fatty acids isobutyrate, n-valerate and isovalerate occurred when Wistar rats were fed an experimental diet containing 5% pectin as the only dietary fibre, compared to rats fed the experimental diet containing no dietary fibre. These large changes in the short chain fatty acid profile, caused by pectin supplementation, have important implications for the metabolism and health of the colon.
当深色刺鼠从含有3.3%粗纤维和4%脂肪的常规颗粒饲料改为含有5%果胶和17%脂肪的实验饲料时，盲肠中丁酸盐的水平迅速下降了五倍多。这种变化可能很重要，因为已知丁酸盐是结肠细胞的主要能量来源，并在体外影响结肠肿瘤细胞的发育。与喂食不含膳食纤维的实验饲料的大鼠相比，当给Wistar大鼠喂食含有5%果胶作为唯一膳食纤维的实验饲料时，盲肠中短链脂肪酸异丁酸、正戊酸和异戊酸的浓度显著降低。由补充果胶引起的短链脂肪酸谱的这些巨大变化，对结肠的代谢和健康具有重要意义。
