粪肠球菌发酵亚种的溶血素有助于小鼠的致病力。
Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice.
作者信息
Ike Y, Hashimoto H, Clewell D B
出版信息
Infect Immun. 1984 Aug;45(2):528-30. doi: 10.1128/iai.45.2.528-530.1984.
Abstract
The conjugative plasmid pAD1 (56.7 kilobases) in Streptococcus faecalis confers hemolysin-bacteriocin (Hly-Bcn) expression and a mating response to the sex pheromone cAD1 excreted by recipient cells. We examined the contribution of hemolysin to pathogenicity in intraperitoneally infected mice by using Tn916 and Tn917 insertion mutants altered in hemolysin expression. Strains exhibiting the normal hemolysin phenotype were significantly more virulent than the nonhemolytic insertion mutants. A mutant plasmid with an increased copy number which gave rise to a larger-than-normal zone of hemolysis on blood agar rendered host strains more virulent than the wild-type streptococci in mice.
摘要
粪肠球菌中的接合质粒pAD1（56.7千碱基）赋予溶血素-细菌素（Hly-Bcn）表达，并对受体细胞分泌的性信息素cAD1产生交配反应。我们通过使用溶血素表达发生改变的Tn916和Tn917插入突变体，研究了溶血素在腹腔感染小鼠中的致病性作用。表现出正常溶血素表型的菌株比非溶血插入突变体的毒力明显更强。在血琼脂上产生比正常更大溶血圈的高拷贝数突变质粒，使宿主菌株在小鼠中的毒力比野生型链球菌更强。
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本文引用的文献
1
PROBABLE IDENTITY OF A GROUP D HEMOLYSIN WITH A BACTERIOCINE.D群溶血素与一种细菌素的可能同一性
J Bacteriol. 1963 Oct;86(4):708-12. doi: 10.1128/jb.86.4.708-712.1963.
2
Haemolysin contributes to virulence of extra-intestinal E. coli infections.溶血素有助于肠道外大肠杆菌感染的致病性。
Nature. 1981 Dec 17;294(5842):665-7. doi: 10.1038/294665a0.
3
Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA.获得质粒DNA后粪肠球菌性信息素的修饰。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5369-73. doi: 10.1073/pnas.80.17.5369.
4
Genetic analysis of the pAD1 pheromone response in Streptococcus faecalis, using transposon Tn917 as an insertional mutagen.使用转座子Tn917作为插入诱变剂对粪肠球菌中pAD1信息素反应进行遗传分析。
J Bacteriol. 1984 Jun;158(3):777-83. doi: 10.1128/jb.158.3.777-783.1984.
5
Broad geographical distribution of a cytotoxin gene mediating beta-hemolysis and bacteriocin activity among Streptococcus faecalis strains.粪链球菌菌株中一种介导β-溶血和细菌素活性的细胞毒素基因的广泛地理分布。
Infect Immun. 1983 Jun;40(3):1015-22. doi: 10.1128/iai.40.3.1015-1022.1983.
6
Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917.粪肠球菌质粒pAD1和pAD2的图谱绘制以及与Tn917转座相关的研究。
J Bacteriol. 1982 Dec;152(3):1220-30. doi: 10.1128/jb.152.3.1220-1230.1982.
7
Plasmids, drug resistance, and gene transfer in the genus Streptococcus.链球菌属中的质粒、耐药性与基因转移
Microbiol Rev. 1981 Sep;45(3):409-36. doi: 10.1128/mr.45.3.409-436.1981.
8
Evidence for conjugal transfer of a Streptococcus faecalis transposon (Tn916) from a chromosomal site in the absence of plasmid DNA.粪肠球菌转座子（Tn916）在无质粒DNA情况下从染色体位点进行接合转移的证据。
Cold Spring Harb Symp Quant Biol. 1981;45 Pt 1:77-80. doi: 10.1101/sqb.1981.045.01.014.
9
Evidence for a chromosome-borne resistance transposon (Tn916) in Streptococcus faecalis that is capable of "conjugal" transfer in the absence of a conjugative plasmid.粪肠球菌中一种染色体携带的抗性转座子（Tn916）的证据，该转座子在没有接合质粒的情况下能够进行“接合”转移。
J Bacteriol. 1981 Jan;145(1):494-502. doi: 10.1128/jb.145.1.494-502.1981.
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Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis.粪肠球菌中红霉素诱导型转座子Tn917的特性
J Bacteriol. 1980 Mar;141(3):1366-74. doi: 10.1128/jb.141.3.1366-1374.1980.
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