Itoh H, Ohtsuka N, Ogita K, Yagi G, Miura S, Koga Y
Folia Psychiatr Neurol Jpn. 1977;31(4):559-76.
Fourteen cases in which hyperpyrexia, akinesia, mutism, extrapyramidal symptoms and severe, diverse autonomic symptoms developed in the course of neuroleptic drug therapy are reported as the malignant neuroleptic syndrome, with analysis and discussion of the clinical features and pathogenic factors. Possible factors contributing to the danger of evoking this syndrome are: 1. Physical exhaustion associated with dehydration, and 2. Parenteral administration of neuroleptic agents, especially of the incisive type. Symptomatologic similarity of the syndrome to the condition known as malignant hyperthermia during anesthesia is also discussed.
报告了14例在抗精神病药物治疗过程中出现高热、运动不能、缄默、锥体外系症状以及严重多样自主神经症状的病例，诊断为恶性抗精神病综合征，并对其临床特征和致病因素进行了分析和讨论。引发该综合征危险的可能因素有：1. 与脱水相关的身体疲惫；2. 胃肠外给予抗精神病药物，尤其是高效价类型。还讨论了该综合征与麻醉期间称为恶性高热的病症在症状学上的相似性。
