Hamai J, Miyahara K, Nishimura H, Yakushiji M, Kato T, Matsumoto K, Okubo K, Yokoyama M
Nihon Sanka Fujinka Gakkai Zasshi. 1984 Jul;36(7):1064-70.
Peripheral blood lymphocyte subsets of 8 patients with ovarian cancer were analyzed before and after chemotherapy by using monoclonal antibody (OKT series) and laser flow cytometer (Spectrum III). The following results were obtained: There was no significant difference in the distribution of OKT3+ and 11+ cells before and after chemotherapy, and between the patient and the control groups. OKT4+ cells were significantly decreased in number after chemotherapy in the patient group when the results were compared with the control (p less than 0.001) and the pretreatment (p less than 0.05) groups respectively. OKT8+ cells were more markedly increased in number after chemotherapy in the patient group (p less than 0.05) than in the control group. OKIal+ cells were more increased in number after chemotherapy in the patient group (p less than 0.01) than the control group. The OKT4+/OKT8+ ratio in the patient group was significantly decreased after chemotherapy when the value was compared with the control (p less than 0.001) and the pretreatment (p less than 0.05) groups.
采用单克隆抗体（OKT系列）和激光流式细胞仪（Spectrum III）对8例卵巢癌患者化疗前后的外周血淋巴细胞亚群进行分析。结果如下：化疗前后及患者与对照组之间OKT3 +和11 +细胞的分布无显著差异。与对照组（p <0.001）和预处理组（p <0.05）相比，患者组化疗后OKT4 +细胞数量显著减少。患者组化疗后OKT8 +细胞数量比对照组增加更明显（p <0.05）。患者组化疗后OKIal +细胞数量比对照组增加更多（p <0.01）。与对照组（p <0.001）和预处理组（p <0.05）相比，患者组化疗后OKT4 + /OKT8 +比值显著降低。
