Hamai J, Yakushiji M, Miyahara K, Okura N, Tazaki T, Nishimura H, Kato T
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Sep;37(9):1875-82.
Immunological function in patients with ovarian cancer was studied using parameters including peripheral blood lymphocyte counts, lymphocyte subsets, PHA-induced lymphoproliferative (PHA-LP) reaction, PPD skin test and immunoglobulin levels. The following results were obtained: The number of total lymphocytes, T cells (OKT 11+) and B cells (OKIa 1+) in peripheral blood were found to be decreased in patients with advanced carcinoma. The positive rate of PPD skin test was also lower in the patients. OKT8+ cells were significantly increased in the disseminated carcinoma (DC) group and the OKT4+/OKT8+ ratio in the DC group was markedly decreased when the results were compared with the control and the patients in the localized carcinoma (LC) group. PHA-LP reaction and serum IgM level in the patients in the LC and DC groups were found to be significantly lower than in the control group. The percentage of T cell (OKT11+), serum IgG and IgA levels were not altered in any clinical stage of the patients.
采用外周血淋巴细胞计数、淋巴细胞亚群、PHA诱导的淋巴细胞增殖（PHA-LP）反应、PPD皮肤试验及免疫球蛋白水平等参数，对卵巢癌患者的免疫功能进行了研究。获得了以下结果：晚期癌患者外周血中总淋巴细胞、T细胞（OKT 11+）和B细胞（OKIa 1+）的数量减少。患者的PPD皮肤试验阳性率也较低。与对照组和局限性癌（LC）组患者相比，播散性癌（DC）组的OKT8+细胞显著增加，且DC组的OKT4+/OKT8+比值明显降低。发现LC组和DC组患者的PHA-LP反应和血清IgM水平显著低于对照组。患者在任何临床分期中，T细胞（OKT11+）百分比、血清IgG和IgA水平均未改变。
