恶臭假单胞菌提取物对人外周血淋巴细胞转化的体外抑制作用
In vitro inhibition of human peripheral blood lymphocyte transformation by an extract of Pseudomonas putida.
作者信息
Hunt C V, Khan W, Friedman G, Houck J C
出版信息
Immunology. 1977 Aug;33(2):209-15.
Abstract
An extract prepared from a psychrophilic strain of Pseudomonas putida was found to cause a dose-dependent inhibition of [H3]TdR incorporation into human peripheral blood lymphocytes stimulated with PHA, ConA, PWM, or in a mixed lymphocyte reaction. The inhibition was found not to be the result of cytotoxicity, culture medium depletion of a component necessary for lymphocyte transformation, or interference with label uptake by blast lymphocytes. The extract was most effective when added prior to 48 h of mitogen stimulation. The inhibitory material was photeolytic enzyme degradable, heat-stable and non-dialyzable.
摘要
从嗜冷性恶臭假单胞菌菌株制备的提取物被发现可导致[H3]TdR掺入经PHA、ConA、PWM刺激的人外周血淋巴细胞或混合淋巴细胞反应中的剂量依赖性抑制。发现该抑制不是细胞毒性、淋巴细胞转化所需成分的培养基耗竭或对母细胞淋巴细胞标记摄取的干扰的结果。当在丝裂原刺激48小时之前添加时，提取物最有效。抑制物质可被光解酶降解、热稳定且不可透析。
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