[心房颤动患者体内内源性前列腺素和环核苷酸的浓度]
[Concentration of endogenous prostanoids and cyclic nucleotides in patients with atrial fibrillation].
作者信息
Smirnov I E, Bunin Iu A, Nargizian A B, Ziabkina A G, Petrovskiĭ P F
出版信息
Kardiologiia. 1984 May;24(5):39-43.
The variations in the content of endogenic prostanoids and cyclic nucleotides in the blood plasma of the coronary sinus and ascending aorta were studied in patients with the idiopathic stable form of atrial fibrillation before and after sinus rhythm recovery effected by electroimpulse therapy. Changes in the levels and ratios of these compounds in the coronary venous and arterial blood were found to be opposite in their trends. A significant elevation in TxB2 levels and the TxB2/6-keto-PGF1 ratio as well as increased cGMP concentrations in the plasma of the coronary venous blood appear to be suggestive of an unfavourable prognosis because patients with such changes developed atrial fibrillation recurrences soon after electroimpulse therapy.
在接受电脉冲治疗恢复窦性心律之前和之后，对特发性稳定型心房颤动患者冠状窦和升主动脉血浆中内源性前列腺素和环核苷酸的含量变化进行了研究。发现这些化合物在冠状静脉血和动脉血中的水平及比率变化趋势相反。冠状静脉血浆中TxB2水平及TxB2/6-酮-PGF1比率显著升高，同时cGMP浓度增加，这似乎提示预后不良，因为有这些变化的患者在电脉冲治疗后不久就出现了心房颤动复发。
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