Pribytkov Iu N, Korshunov N I, Frizen B N
Ter Arkh. 1991;63(10):149-53.
The content of cyclic nucleotides in blood plasma was measured in 151 patients suffering from rheumatoid arthritis. As compared to the control, the patients demonstrated a significant decrease of the cAMP content and a rise of the cGMP content. The disease standing was found to produce an appreciable effect on the cAMP content. RA patients untreated with glucocorticoids manifested significant correlations between the content of cyclic nucleotides and some characteristics of inflammation and of the immune status. At the same time the majority of such correlations may be lost under conditions of hormonal dependence, which is likely to attest to dysregulation of inflammatory process. In the course of the treatment, the content of cAMP in the plasma increase is attended by a reduction increases in 63.8% of the patients. In the majority of them, that of the level of circulating immune complexes, thereby supporting the relationship between immunopathological and metabolic disorders at the cellular level.
对151例类风湿性关节炎患者的血浆环核苷酸含量进行了测定。与对照组相比，患者的环磷酸腺苷（cAMP）含量显著降低，环磷酸鸟苷（cGMP）含量升高。发现疾病状态对cAMP含量有明显影响。未接受糖皮质激素治疗的类风湿性关节炎（RA）患者，其环核苷酸含量与炎症及免疫状态的某些特征之间存在显著相关性。同时，在激素依赖的情况下，大多数此类相关性可能会消失，这可能证明炎症过程失调。在治疗过程中，63.8%的患者血浆中cAMP含量增加的同时，循环免疫复合物水平降低，从而支持了细胞水平上免疫病理和代谢紊乱之间的关系。
