Melius P
Natl Cancer Inst Monogr. 1984 May;65:387-90.
Benzo[a]pyrene is converted to 3-hydroxybenzo[a]pyrene, 9-hydroxybenzo[a]pyrene, benzo[a]pyrene-4,5-dihydrodiol, benzo[a]pyrene-7,8-dihydrodiol, benzo[a]pyrene-9,10-dihydrodiol, and benzo[a]pyrene quinones by postmitochondrial supernatant or microsomes in such fish as the rainbow trout, flounder, salmon, mullet, little skate, Fundulus grandis, and sea catfish. It is also now well-established that many fish convert benzo[a]pyrene to potent mutagenic metabolites as has been demonstrated with the Ames test, especially when the fish are induced with Aroclor 1254 or 3-methylcholanthrene. The metabolite patterns obtained at different substrate concentrations levels indicate that the metabolism is more complex at low concentrations when metabolites are recycled in the in vitro system.
在虹鳟鱼、比目鱼、鲑鱼、鲻鱼、小鳐鱼、大眼底鳉和海鲶等鱼类中，苯并[a]芘可被线粒体后上清液或微粒体转化为3 - 羟基苯并[a]芘、9 - 羟基苯并[a]芘、苯并[a]芘 - 4,5 - 二氢二醇、苯并[a]芘 - 7,8 - 二氢二醇、苯并[a]芘 - 9,10 - 二氢二醇和苯并[a]芘醌。现在也已充分证实，许多鱼类会将苯并[a]芘转化为具有强致突变性的代谢产物，如艾姆斯试验所证明的那样，尤其是当鱼类用多氯联苯混合物1254或3 - 甲基胆蒽诱导时。在不同底物浓度水平下获得的代谢产物模式表明，当代谢产物在体外系统中循环时，低浓度下的代谢更为复杂。
