感染后2年半在小鼠脊髓中检测到泰勒氏病毒抗原。
Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection.
作者信息
Lipton H L, Kratochvil J, Sethi P, Dal Canto M C
出版信息
Neurology. 1984 Aug;34(8):1117-9. doi: 10.1212/wnl.34.8.1117.
PMID:6087205
Abstract
Spinal cord sections from mice injected with Theiler's murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2 1/2 years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque-forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.
摘要
对感染泰勒小鼠脑脊髓炎病毒（TMEV）并在感染后存活1年及更长时间的小鼠脊髓切片，采用两种免疫组织化学技术对病毒抗原进行染色。在感染后1至2年半期间可检测到病毒抗原，而此时以每克组织50个蚀斑形成单位的检测灵敏度却未检测到病毒。文中讨论了这一结果对于在多发性硬化症中检测病毒的意义。
Zotero 插件