吲哚美辛可增强组胺刺激的兔离体胃底腺产酸。
Indomethacin enhances histamine-stimulated acid production in rabbit isolated fundic glands.
作者信息
Schwartzel E H, Levine R A, Schwartz S E, Ganley C E
出版信息
Prostaglandins Leukot Med. 1984 Jun;14(3):383-90. doi: 10.1016/0262-1746(84)90121-5.
The effects of 10(-4)M indomethacin on tissue prostaglandin E2 levels, cyclic AMP concentrations, and acid secretion as measured by the intraglandular accumulation of [14C]aminopyrine were evaluated in unstimulated and histamine-stimulated isolated rabbit fundic glands. Indomethacin (10(-4)M) reduced endogenous prostaglandin E2 content by 52% in unstimulated glands. Indomethacin tripled histamine (10(-6)-10(-4)M-stimulated aminopyrine uptake while not affecting aminopyrine accumulation in unstimulated glands. Indomethacin did not affect cyclic AMP levels in either the unstimulated or stimulated condition.
通过[14C]氨基比林在腺体内的蓄积来测定，评估了10(-4)M消炎痛对未刺激和组胺刺激的离体兔胃底腺中组织前列腺素E2水平、环磷酸腺苷浓度及酸分泌的影响。消炎痛（10(-4)M）使未刺激腺体中的内源性前列腺素E2含量降低了52%。消炎痛使组胺（10(-6)-10(-4)M）刺激的氨基比林摄取增加了两倍，而不影响未刺激腺体中氨基比林的蓄积。消炎痛在未刺激或刺激状态下均不影响环磷酸腺苷水平。
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