Rice H E, Smith C B, Silk K R, Rosen J
Psychiatry Res. 1984 May;12(1):69-77. doi: 10.1016/0165-1781(84)90139-2.
The specific binding to isolated platelet membranes of 3H-clonidine, an alpha 2-adrenergic receptor partial agonist, and 3H-yohimbine, an alpha 2-adrenergic receptor antagonist, was measured in male, drug-free schizophrenic patients. The maximum number of binding sites (Bmax) for 3H-yohimbine was significantly lower in these patients than in normal subjects. Treatment with chlorpromazine (CPZ) for 2 weeks further decreased the Bmax for both ligands. Plasma catecholamine levels were determined before and after treatment. Before treatment, levels of dopamine and norepinephrine (NE) were within a normal range, while epinephrine (E) levels were significantly elevated. CPZ treatment significantly increased plasma NE levels, but decreased E levels to a normal range. These observations suggest that schizophrenia might be associated with abnormal noradrenergic function that is reflected by a decreased number of platelet alpha 2-adrenergic receptors.
在未服用药物的男性精神分裂症患者中，测定了α2-肾上腺素能受体部分激动剂3H-可乐定和α2-肾上腺素能受体拮抗剂3H-育亨宾与分离的血小板膜的特异性结合。这些患者中3H-育亨宾的最大结合位点数（Bmax）显著低于正常受试者。用氯丙嗪（CPZ）治疗2周后，两种配体的Bmax进一步降低。测定了治疗前后的血浆儿茶酚胺水平。治疗前，多巴胺和去甲肾上腺素（NE）水平在正常范围内，而肾上腺素（E）水平显著升高。CPZ治疗显著提高了血浆NE水平，但将E水平降至正常范围。这些观察结果表明，精神分裂症可能与异常的去甲肾上腺素能功能有关，这表现为血小板α2-肾上腺素能受体数量减少。
