Smith C B, Hollingsworth P J, Garcia-Sevilla J A, Zis A P
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):241-7. doi: 10.1016/0278-5846(83)90114-8.
Specific binding of 3H-clonidine to alpha 2 adrenoreceptors upon human blood platelet membranes is increased in patients with major depressive disorder (endogenous depression). Specific binding of 3H-yohimbine to the platelet adrenoreceptor is not altered in endogenously depressed patients. Other psychiatric disorders are not associated with alterations in the specific binding of either 3H-clonidine or 3H-yohimbine. In patients with severe congestive heart failure or with symptomatic coronary artery disease the number of platelet alpha 2 adrenoreceptors is actually decreased. Treatment of endogenously depressed patients with tricyclic antidepressants, lithium salts or electroconvulsive therapy results in a decrease in the number of alpha 2 adrenoreceptors on blood platelet membranes. These studies suggest that a supersensitivity of the alpha 2 adrenoreceptor might exist in patients with endogenous depression and that effective forms of therapy lead to a decrease in the number of neural alpha 2 adrenoreceptors which is reflected by a decrease in the number of these receptors upon blood platelet membranes.
在重度抑郁症（内源性抑郁症）患者中，人血小板膜上3H-可乐定与α2肾上腺素能受体的特异性结合增加。内源性抑郁症患者中，3H-育亨宾与血小板肾上腺素能受体的特异性结合未发生改变。其他精神疾病与3H-可乐定或3H-育亨宾特异性结合的改变无关。在严重充血性心力衰竭或有症状性冠状动脉疾病的患者中，血小板α2肾上腺素能受体的数量实际上会减少。用三环类抗抑郁药、锂盐或电休克疗法治疗内源性抑郁症患者会导致血小板膜上α2肾上腺素能受体数量减少。这些研究表明，内源性抑郁症患者可能存在α2肾上腺素能受体超敏反应，有效的治疗形式会导致神经α2肾上腺素能受体数量减少，这通过血小板膜上这些受体数量的减少得以体现。
