Souhrada M, Souhrada J F
Science. 1984 Aug 17;225(4663):723-5. doi: 10.1126/science.6087455.
Active and passive sensitization, both in vivo and in vitro, caused significant hyperpolarization of airway smooth muscle cell preparations isolated from guinea pigs. An increase in the contribution of the electrogenic Na+ pump to the resting membrane potential was responsible for this change. Hyperpolarization, as induced by passive sensitization, was not prevented by agents that inhibit specific mediators of anaphylaxis but was abolished when serum from sensitized animals was heated. The heat-sensitive serum factor, presumably reaginic antibodies, appears to be responsible for the membrane hyperpolarization of airway smooth muscle cells after sensitization.
体内和体外的主动致敏和被动致敏均导致从豚鼠分离的气道平滑肌细胞制剂出现显著的超极化。这种变化是由电生性钠泵对静息膜电位的贡献增加所致。被动致敏诱导的超极化不受抑制过敏反应特异性介质的药物的阻止，但当致敏动物的血清加热后，超极化消失。这种热敏感的血清因子，可能是反应素抗体，似乎是致敏后气道平滑肌细胞膜超极化的原因。
