Meyer B H, Müller F O, Kruger J B, Clur B K, Grigoleit H G
S Afr Med J. 1984 Aug 11;66(6):222-3.
Nine volunteers participated in a double-blind, cross-over study to compare the effects of tendamistate (HOE 467), guar and placebo on starch metabolism. In each phase of the trial they received a maize-meal porridge breakfast. They either received 5 g guar granules before the porridge or 100 mg tendamistate mixed with the porridge, or porridge alone. Sequential plasma glucose concentrations served as a criterion of starch digestion. The area under the plasma glucose curve and maximal glucose concentrations after administration of tendamistate with the starch were significantly lower (P less than 0,05) than after guar and placebo. No significant differences were found between placebo and guar. We concluded that tendamistate effectively attenuates starch digestion and is superior to guar in reducing postprandial glycaemia.
九名志愿者参与了一项双盲交叉研究，以比较坦达米酯（HOE 467）、瓜尔豆胶和安慰剂对淀粉代谢的影响。在试验的每个阶段，他们都食用玉米粉粥作为早餐。他们要么在粥前服用5克瓜尔豆胶颗粒，要么将100毫克坦达米酯与粥混合服用，要么只服用粥。连续的血浆葡萄糖浓度作为淀粉消化的标准。与淀粉一起服用坦达米酯后，血浆葡萄糖曲线下面积和最大葡萄糖浓度显著低于瓜尔豆胶和安慰剂组（P<0.05）。安慰剂和瓜尔豆胶之间未发现显著差异。我们得出结论，坦达米酯能有效减弱淀粉消化，在降低餐后血糖方面优于瓜尔豆胶。
