Meyer B H, Müller F O, Kruger J B, Grigoleit H G
S Afr Med J. 1984 Feb 25;65(8):287-8.
Six healthy male volunteers participated in a double-blind cross-over study in which 12,5 mg, 25 mg, or 50 mg tendamistate (HOE 467), an alpha-amylase inactivator, or placebo were administered with 100 g maize meal, which contains 85,5 g pure starch. Serial blood specimens for measurement of plasma glucose concentrations, which served as a criterion of starch absorption, were taken up to 3 hours after each starch meal, and side-effects were recorded. The administration of HOE 467 with a starch meal resulted in a significant inhibition of starch absorption. Side-effects were not severe. Flatulence occurred in the placebo phase as well as after administration of the active drug. Loose stools were reported by 1 subject after 25 mg tendamistate.
六名健康男性志愿者参与了一项双盲交叉研究，在该研究中，12.5毫克、25毫克或50毫克的tendamistate（HOE 467，一种α-淀粉酶灭活剂）或安慰剂与100克玉米粉（其中含有85.5克纯淀粉）一起服用。在每次淀粉餐后长达3小时采集用于测量血浆葡萄糖浓度的系列血样，血浆葡萄糖浓度作为淀粉吸收的标准，并记录副作用。HOE 467与淀粉餐一起服用导致淀粉吸收受到显著抑制。副作用不严重。安慰剂阶段以及服用活性药物后均出现肠胃胀气。一名受试者在服用25毫克tendamistate后报告有腹泻。
