Shike M, Russel D M, Detsky A S, Harrison J E, McNeill K G, Shepherd F A, Feld R, Evans W K, Jeejeebhoy K N
Ann Intern Med. 1984 Sep;101(3):303-9. doi: 10.7326/0003-4819-101-3-303.
y composition was studied in 31 patients receiving chemotherapy for small-cell lung cancer. Patients were randomly assigned to receive either 4 weeks of total parenteral nutrition (study group) or to continue a self-regulated oral diet (control group). The relationship between height and total body nitrogen was altered initially for patients who had lost more than 5% of body weight. During the 4 weeks of parenteral nutrition, body weight, total body fat, and total body potassium, but not total body nitrogen, increased significantly in the study group (p less than 0.001). However, after parenteral nutrition was stopped, body weight and potassium levels in the study group fell significantly and to the same extent as in the control group. Nitrogen levels showed an overall fall in the 32 weeks of observation for both groups. After the period of parenteral nutrition, the decrease in body fat was significantly greater in the control group than in the study group (p less than 0.05). Thus, parenteral nutrition increased body fat and total body potassium, but not total body nitrogen.
对31例接受小细胞肺癌化疗的患者的身体成分进行了研究。患者被随机分配接受为期4周的全胃肠外营养（研究组）或继续自行调节的口服饮食（对照组）。体重减轻超过5%的患者，其身高与全身氮含量之间的关系最初发生了改变。在胃肠外营养的4周期间，研究组的体重、全身脂肪和全身钾含量显著增加，但全身氮含量未增加（p<0.001）。然而，停止胃肠外营养后，研究组的体重和钾水平显著下降，且下降幅度与对照组相同。在32周的观察期内，两组的氮含量总体均呈下降趋势。胃肠外营养期结束后，对照组的体脂减少幅度明显大于研究组（p<0.05）。因此，胃肠外营养增加了体脂和全身钾含量，但未增加全身氮含量。
