Baldissera F
Arch Ital Biol. 1984 Mar;122(1):43-58.
Like receptors, neurones of the mammalian CNS react to both the static and the dynamic features of the input signals. The quantitative aspect of the current-to-frequency transduction during input transients were analyzed in spinal motoneurones and in corticospinal neurones by the technique of injecting intracellularly either ramp of sine-wave currents. It was found that, in both types of neurones, the instantaneous firing frequency is linearly correlated, within definite ranges, both to the intensity and to the velocity of change of the input currents. By recording the isometric mechanogram of the muscle units innervated by the impaled motoneurones, it was disclosed that the motoneurones discharges produced by the ramp currents develop tension changes, whose average velocity is proportional to the ramp slope. For both types of neurones, results are consistent with the hypothesis that the major determinants of the double sensitivity, to the intensity and to the velocity, are the kinetics of the potassium conductance system responsible for the spike afterhyperpolarization.
与感受器一样，哺乳动物中枢神经系统的神经元对输入信号的静态和动态特征都会产生反应。通过向脊髓运动神经元和皮质脊髓神经元细胞内注入正弦波电流斜坡的技术，分析了输入瞬变期间电流到频率转换的定量方面。结果发现，在这两种类型的神经元中，在一定范围内，瞬时放电频率与输入电流的强度和变化速度均呈线性相关。通过记录由被刺穿的运动神经元所支配的肌肉单位的等长机械图，发现斜坡电流产生的运动神经元放电会引起张力变化，其平均速度与斜坡斜率成正比。对于这两种类型的神经元，结果都与以下假设一致：对强度和速度双重敏感性的主要决定因素是负责动作电位后超极化的钾电导系统的动力学。
