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[局部放疗联合一次性高剂量上半身及下半身照射治疗不可切除的小细胞支气管癌]

[Treatment of inoperable small-cell bronchial carcinoma with local radiotherapy and supplementary high-dosage one-time upper and lower half-body irradiation].

作者信息

Hüttner J, Eichhorn H J, Dallüge K H, Grunau H

出版信息

Arch Geschwulstforsch. 1984;54(3):239-42.

PMID:6087768
Abstract

37 patients with histologically verified inoperable small-cell bronchial carcinomas were treated with local tumor irradiation (40 Gy), combined with upper and lower half-body irradiation. Continuous analysis of the treatment results led to modification of therapy, from which two groups of patients resulted. In group I the whole-body treatment consisted of an irradiation of the upper, and six weeks later, of the lower half of the body with a dose of 8.8 Gy. In group 2 the half-body dose of 8.8 Gy was applied in 2 fractions on the same day (6.0 Gy, break of 5 hours, 2.0 Gy). The critical organ was the lung: the pneumonitis rate and the effect on tumor and metastases and survival times are reported.

摘要

37例经组织学证实无法手术的小细胞支气管癌患者接受了局部肿瘤照射(40 Gy),并结合上半身和下半身照射。对治疗结果的持续分析导致了治疗方案的调整,由此产生了两组患者。在第一组中,全身治疗包括先对上半身进行照射,六周后再对下半身进行照射,剂量为8.8 Gy。在第二组中,8.8 Gy的半身剂量在同一天分两次给予(6.0 Gy,间隔5小时,2.0 Gy)。关键器官是肺:报告了肺炎发生率、对肿瘤和转移灶的影响以及生存时间。

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