Merregaert J, Michiels L, Pedersen F S, de Saint-Georges L, Janowski M, Maisin J R
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The induction of osteosarcomas with 90Sr in CF1 mice is associated with the expression of ecotropic type-C RNA viruses devoid of sarcomatogenic activity. In contrast, the FBR murine osteosarcoma virus complex, isolated from a 90 Sr-induced osteosarcoma of a X/Gf mouse [M. Finkel et al. (1)], causes the rapid appearance of osteosarcomas in newborn mice and transforms fibroblasts in vitro. The transforming capacity of FBR murine sarcoma virus has been associated as an oncogene homologous to v-fos.
用90Sr在CF1小鼠中诱导骨肉瘤与缺乏肉瘤生成活性的嗜亲性C型RNA病毒的表达有关。相比之下，从一只X/Gf小鼠的90Sr诱导的骨肉瘤中分离出的FBR鼠骨肉瘤病毒复合物[M. 芬克尔等人（1）]，可使新生小鼠迅速出现骨肉瘤，并在体外转化成纤维细胞。FBR鼠肉瘤病毒的转化能力与一种与v-fos同源的癌基因有关。
