Reif A E, Triest W E
J Natl Cancer Inst. 1983 Sep;71(3):545-52.
The thesis was tested that immunization against a murine osteosarcoma virus can reduce the incidence of bone tumors induced by 90Sr. C57BL/6J female mice (190) were divided into three sets of 2 groups. Each set consisted of a control group and an experimental group treated ip with 1.0 muCi 90Sr at 66 days of age. The three sets of groups received the following additional treatments: none (controls), 6 injections of Formalin-inactivated FBJ osteosarcoma virus (vaccinated group), or 6 injections of active FBJ virus (active virus controls). Only 1 bone tumor developed in a mouse not treated with 90Sr in the active virus controls. In 90Sr-treated mice, vaccination reduced bone tumor deaths during the first 600 days from 9 of 36 in controls to 1 of 33 in vaccinated mice (P less than .01), but bone tumor deaths during the entire life-span, 10 of 36 and 5 of 33, respectively, were not significantly different (P = .07). Thus the vaccination procedure delayed the development of bone tumors. In contrast, injection of active virus into 90Sr-treated mice increased the lifetime incidence of bone tumors from 10 of 36 in controls to 19 of 32 (P = .01).
本论文验证了针对鼠骨肉瘤病毒的免疫接种能否降低由90锶诱导的骨肿瘤发病率。将190只C57BL/6J雌性小鼠分为三组，每组2个小组。每组均包含一个对照组和一个在66日龄时腹腔注射1.0微居里90锶的实验组。这三组小鼠接受了以下额外处理：无额外处理（对照组）、6次注射福尔马林灭活的FBJ骨肉瘤病毒（接种疫苗组）或6次注射活性FBJ病毒（活性病毒对照组）。在活性病毒对照组中，未接受90锶处理的小鼠仅发生了1例骨肿瘤。在接受90锶处理的小鼠中，接种疫苗使前600天内骨肿瘤死亡数从对照组36只中的9只降至接种疫苗小鼠33只中的1只（P小于0.01），但在整个寿命期内，对照组36只中有10只、接种疫苗组33只中有5只发生骨肿瘤死亡，二者无显著差异（P = 0.07）。因此，接种疫苗程序延缓了骨肿瘤的发生。相比之下，向接受90锶处理的小鼠注射活性病毒使骨肿瘤终生发病率从对照组36只中的10只增至32只中的19只（P = 0.01）。
