Spitzer G, Dicke K, Zander A R, Jagannath S, Vellekoop L, Freireich E J
Cancer. 1984 Sep 15;54(6 Suppl):1216-25. doi: 10.1002/1097-0142(19840915)54:1+<1216::aid-cncr2820541320>3.0.co;2-e.
High-dose chemotherapy using drugs with predominant marrow toxicity and autologous bone marrow support has been investigated in a number of tumor types. High response rates are uniform and complete responses are also high; but long-term disease-free survival is occasional. This review discusses those tumor types where patients treated with this approach have survived disease free for several years. Also discussed is what other tumor types and prognostic subgroups of those tumors might benefit therapeutically from high-dose cytotoxic intensification with autologous bone marrow support or at least have this approach considered as the first alternative for initial relapse.
使用具有主要骨髓毒性的药物及自体骨髓支持的大剂量化疗已在多种肿瘤类型中进行了研究。高反应率一致，完全缓解率也很高；但长期无病生存情况较为少见。本综述讨论了采用这种方法治疗的患者已无病存活数年的肿瘤类型。还讨论了其他哪些肿瘤类型以及这些肿瘤的预后亚组可能从自体骨髓支持的大剂量细胞毒性强化治疗中在治疗上获益，或者至少将这种方法视为初始复发的首选替代方案。
