Mowbray J, Perrett D, Bates D J
Int J Biochem. 1984;16(8):889-94. doi: 10.1016/0020-711x(84)90148-4.
Langendorff perfused rat hearts show synchronous, statistically significant, systematic variations in ATP and ADP. Here we show that AMP and IMP also vary in register with ATP and ADP and we suggest that the synchronizing trigger for these oscillations may be ischaemia. Oscillations in the ATP/ADP ratio were found to be significantly correlated with creatine phosphate content but by contrast these quantities vary quite differently from the GTP/GDP ratio. Cyclic GMP oscillations showed a significant negative correlation with variations in ADP. Epinephrine raised mean cyclic AMP content and stabilized cyclic GMP oscillations, but had little other effect on the purine nucleotide variations.
Langendorff灌注的大鼠心脏显示出ATP和ADP存在同步、具有统计学意义的系统性变化。在此我们表明，AMP和IMP也与ATP和ADP同步变化，并且我们认为这些振荡的同步触发因素可能是局部缺血。发现ATP/ADP比值的振荡与磷酸肌酸含量显著相关，但相比之下，这些量与GTP/GDP比值的变化差异很大。环鸟苷酸（cGMP）振荡与ADP的变化呈显著负相关。肾上腺素提高了平均环磷酸腺苷（cAMP）含量并稳定了cGMP振荡，但对嘌呤核苷酸变化几乎没有其他影响。
