Brenner M, Padh H
J Cyclic Nucleotide Protein Phosphor Res. 1983;9(4-5):297-303.
Cyclic AMP (cAMP) has been postulated to regulate many of the events in the development of the eukaryotic social ameba Dictyostelium discoideum. The various suggested roles of cAMP could be tested were it possible to reversibly elevate cAMP levels in the organism. To this end we examined the effect of forskolin, which activates the adenylate cyclase of many eukaryotic organisms. We found, however, that the drug does not elevate cAMP levels in intact D. discoideum. In addition, it does not stimulate the adenylate cyclase in either its basal state or activated state.
环磷酸腺苷（cAMP）被认为可调节真核生物社会性变形虫盘基网柄菌发育过程中的许多事件。如果能够在该生物体中可逆地提高cAMP水平，那么就可以对cAMP的各种假定作用进行测试。为此，我们研究了毛喉素的作用，它可激活许多真核生物的腺苷酸环化酶。然而，我们发现该药物并不会提高完整的盘基网柄菌中的cAMP水平。此外，它在基础状态或激活状态下均不会刺激腺苷酸环化酶。
