Daly J W
Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:81-9.
The potential of forskolin as a research tool is just beginning to be realized. Its use has revealed further subtleties to the control of cyclic AMP generation by adenylate cyclase in both solubilized and membrane preparations and in intact cells. It appears that an effect of forskolin will become one of the criteria for implicating adenylate cyclase in any physiological or biochemical response or, conversely, in ruling out an involvement of cyclic AMP. Clinical applications of forskolin as a hypotensive, spasmolytic, lipolytic, or antithrombotic agents or for the treatment of glaucoma or cardiac insufficiency remain other challenges for the future.
福司可林作为一种研究工具的潜力才刚刚开始被认识到。它的应用揭示了在溶解制剂、膜制剂以及完整细胞中，腺苷酸环化酶对环磷酸腺苷生成调控的更多细微之处。看来，福司可林的作用将成为在任何生理或生化反应中牵涉腺苷酸环化酶的标准之一，反之，也可用于排除环磷酸腺苷的参与。福司可林作为降压药、解痉药、脂解剂或抗血栓剂，或用于治疗青光眼或心脏功能不全的临床应用，仍是未来的其他挑战。
