Cottrell G A, Veldhuis H D, Rostene W H, de Kloet E R
Neuropeptides. 1984 Jun;4(4):331-41. doi: 10.1016/0143-4179(84)90008-8.
The effect of vasoactive intestinal peptide (VIP) was studied on fear-motivated behaviours, exploration of a novel environment and on novelty and ACTH-induced grooming. VIP was administered via a plastic cannula into the lateral ventricle. Retention of a step-through passive avoidance task was inhibited by 10 and 30 ng VIP injected 1 hour before the retention test. Extinction of pole-jumping active avoidance behaviour was facilitated by 10 and 100 ng VIP. Mild effects were observed in an open field test on exploration and grooming activity. In conclusion, VIP produces inhibitory effects on fear-motivated behaviours.
研究了血管活性肠肽（VIP）对恐惧驱动行为、新环境探索以及新奇和促肾上腺皮质激素诱导的梳理行为的影响。通过塑料套管将VIP注入侧脑室。在记忆测试前1小时注射10和30纳克VIP可抑制穿梭式被动回避任务的记忆。10和100纳克VIP促进了跳杆主动回避行为的消退。在旷场试验中观察到对探索和梳理活动有轻微影响。总之，VIP对恐惧驱动行为产生抑制作用。
