Gozes I, Bachar M, Bardea A, Davidson A, Rubinraut S, Fridkin M
Dept. Clin. Biochem. Sackler Med. Sch. Tel Aviv Univ., Israel.
Neurochem Res. 1998 May;23(5):689-93. doi: 10.1023/a:1022494907001.
Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vivo using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.
硬脂酰 - Nle - 血管活性肠肽（SNV）是一种新型的血管活性肠肽（VIP）激动剂，其效力比母体分子高100倍，且对与神经元存活相关的受体具有特异性。在此，我们使用两种发育迟缓模型（缺氧和胆碱能阻断）在体内研究了SNV的发育和保护作用。在这两种情况下，发育期间长期给予SNV均具有保护作用。对断奶动物进行的水迷宫实验表明，SNV具有预防作用，并能增强暴露于胆碱毒素的动物的空间记忆。SNV可能通过提供神经保护作用来发挥作用，从而改善认知功能。这项工作献给R.J. 沃特曼教授，他在神经科学和认知领域的灵感和领导力无与伦比。
