Filaretov A A, Bogdanov A I
Probl Endokrinol (Mosk). 1984 Jul-Aug;30(4):56-9.
Injection of hydrocortisone in supraphysiological doses (10 mg twice a day for 2 days) to rabbits produced long-term disorders in hypophyseal-adrenocortical function. The time-course of changes in the blood corticosteroid basal level, the adrenocortical reactivity to ACTH and the ability of the hypophyseal-adrenocortical system to respond to immobilization were investigated. The three periods were detected after hydrocortisone injection, characterizing hypophyseal-adrenocortical function. During the 1st period, the adrenocortical reactivity was inhibited and the response to the stressor was absent in the presence of a normal blood corticosteroid basal content. Within the 2nd period, the corticosteroid basal level was higher than that of the control animals, the adrenocortical reactivity to ACTH arose, but the response to the stressor was absent. At the 3d period all the three parameters under study began returning to normal.
给兔子注射超生理剂量的氢化可的松（每天两次，每次10毫克，共2天）会导致垂体 - 肾上腺皮质功能出现长期紊乱。研究了血液皮质类固醇基础水平的变化时间进程、肾上腺皮质对促肾上腺皮质激素（ACTH）的反应性以及垂体 - 肾上腺皮质系统对固定应激的反应能力。注射氢化可的松后检测到三个时期，其特征为垂体 - 肾上腺皮质功能。在第一个时期，肾上腺皮质反应性受到抑制，在血液皮质类固醇基础含量正常的情况下对应激源无反应。在第二个时期，皮质类固醇基础水平高于对照动物，肾上腺皮质对ACTH的反应性出现，但对应激源无反应。在第三个时期，所有三个研究参数开始恢复正常。
