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应激性胃溃疡的形成与下丘脑-垂体-肾上腺皮质系统功能的关系

[The dependence of the formation of stress stomach ulcers on the function of the hypothalamo-hypophyseal-adrenal cortical system].

作者信息

Filaretova L P

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1990 Nov;76(11):1594-600.

PMID:1964432
Abstract

The effect of supraphysiological doses of corticosteroids on mucosal ulceration of stomach was studied in rats. Cortisol (30 mg/100 g) blocked the PACS. During the PACS block, ulcerogenic properties of stressor increased. This effect was reduced by subsequent corticosterone replacement therapy. The new concept of supraphysiological doses of corticosteroids effect is discussed. The stomach ulceration seems to result from the corticosteroid insufficiency.

摘要

在大鼠中研究了超生理剂量的皮质类固醇对胃黏膜溃疡的影响。皮质醇（30毫克/100克）阻断了应激性急性胃黏膜病变（PACS）。在PACS阻断期间，应激源的致溃疡特性增强。随后的皮质酮替代疗法减轻了这种效应。讨论了超生理剂量皮质类固醇作用的新概念。胃溃疡似乎是由皮质类固醇不足引起的。

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[The dependence of the formation of stress stomach ulcers on the function of the hypothalamo-hypophyseal-adrenal cortical system].应激性胃溃疡的形成与下丘脑-垂体-肾上腺皮质系统功能的关系
Fiziol Zh SSSR Im I M Sechenova. 1990 Nov;76(11):1594-600.
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