Hall C, Mørkrid L, Kjekshus J
Scand J Urol Nephrol Suppl. 1984;79:121-4.
Acute left ventricular failure was induced in 7 anaesthetized dogs by embolization of the left coronary circulation with 57 micron plastic microspheres. The dogs were then subjected to ACE-inhibition with enalapril. In addition to hemodynamic measurements, tissue blood flow was measured with the radioactive microsphere method. Preliminary results are presented, showing the vasodilatory effects of enalapril to be greatest in stomach, muscle and brain while possibly compromising the renal circulation.
通过用57微米的塑料微球栓塞左冠状动脉循环，在7只麻醉的狗身上诱发急性左心室衰竭。然后用依那普利对这些狗进行ACE抑制治疗。除了进行血流动力学测量外，还用放射性微球法测量组织血流量。给出了初步结果，显示依那普利的血管舒张作用在胃、肌肉和大脑中最大，同时可能会损害肾循环。
