Medvedev O S, Zakharova N V
Eksp Klin Farmakol. 1994 Nov-Dec;57(6):26-9.
The present study was undertaken to determine the effect of oral perindopril, 2 mg/kg, on systemic and regional hemodynamics by the radioactive microsphere (15 mu in conscious rats with chronic heart failure and falsely operated-on rats. Experimental heart failure was induced by embolization of coronary vessels with microspheres 21 days before the experiment. The results were compared with those obtained from rats subjected to sham surgical procedures. In congestive heart failure group, perindopril reduced mean blood pressure, total peripheral resistance and end-diastolic left ventricular pressure. Cardiac index was enhanced. Blood flow in the kidney, right ventricle, small intestine of the heart failure rats treated was increased. In sham-operated animals, perindopril reduced mean blood pressure, cardiac output, total peripheral resistance, systolic pressure, diastolic pressure and unchanged renal blood flow. At the same time perindopril unchanged blood flow in the skeletal muscles and brain in the sham-operated animals or heart failure rats. The agent reduced cerebrovascular resistance only in the embolization group.
本研究旨在通过放射性微球（15μm）测定2mg/kg口服培哚普利对清醒慢性心力衰竭大鼠和假手术大鼠全身及局部血流动力学的影响。实验性心力衰竭通过在实验前21天用微球栓塞冠状动脉诱导。将结果与假手术大鼠的结果进行比较。在充血性心力衰竭组中，培哚普利降低了平均血压、总外周阻力和舒张末期左心室压力。心脏指数增加。治疗的心力衰竭大鼠的肾脏、右心室、小肠血流增加。在假手术动物中，培哚普利降低了平均血压、心输出量、总外周阻力、收缩压、舒张压，肾血流量未改变。同时，培哚普利对假手术动物或心力衰竭大鼠的骨骼肌和脑血流无影响。该药物仅在栓塞组降低了脑血管阻力。
