Front D, Israel O, Groshar D, Weininger J
Semin Nucl Med. 1984 Jul;14(3):226-50. doi: 10.1016/s0001-2998(84)80017-3.
Red blood cells labeled with 99mTc constitute a suitable intravascular agent for imaging of vascular abnormalities. Hemangiomas are characterized by low perfusion and a high blood pool. This "perfusion blood-pool mismatch," not encountered in other lesions, may help in the specific diagnosis of this tumor. This is particularly so in cavernous hemangiomas of the liver where three-phase 99mTc-labeled red blood cell scintigraphy should precede liver biopsy. Red cell scintigraphy also is useful for establishing the vascular nature of hemangiomas of the head and neck and the skin and for diagnosis of venous occlusion. Heat-damaged red blood cells provide a specific spleen imaging agent. This should be used when patients with suspected splenic pathology have equivocal colloid scintigraphy.
用99mTc标记的红细胞构成一种适用于血管异常成像的血管内造影剂。血管瘤的特征是灌注低和血池高。这种“灌注-血池不匹配”在其他病变中未见到，可能有助于该肿瘤的特异性诊断。在肝脏海绵状血管瘤中尤其如此，在进行肝活检之前应先进行三相99mTc标记红细胞闪烁扫描。红细胞闪烁扫描对于确定头颈部和皮肤血管瘤的血管性质以及诊断静脉闭塞也很有用。热损伤的红细胞提供一种特异性的脾脏显像剂。当疑似脾脏病变的患者胶体闪烁扫描结果不明确时应使用这种显像剂。
