Myopathies caused by three mutations of the mouse.

Our studies indicate that comparison of the three hereditary myopathies in mice, dy and dy2J, and myd, may provide clues for the fact that "muscular dystrophy" of man defines a group of disorders having both similar and individual characteristics. We have previously suggested that multiple or pleiotropic gene effects as well as interaction of genes may occur not only in mice but also in man. In addition, more than one gene may control or influence pathways of muscle metabolism.