Papadoyannakis N J, Stefanidis C J, McGeown M
Am J Clin Nutr. 1984 Sep;40(3):623-7. doi: 10.1093/ajcn/40.3.623.
Nitrogen and potassium balance studies were conducted in six nondialyzed uremic patients. Each patient was investigated before and after supplementation with sodium bicarbonate and sodium chloride. Every period of the study lasted longer than 1 wk. Each patient had the same calorie and protein intake during the whole study. Urea nitrogen appearance was correlated with protein intake for the assessment of the compliance of patients with their diets. There was a significant decrease of blood urea nitrogen (p = 0.014) of 36% during bicarbonate supplementation and both metabolic balance studies improved significantly (p = 0.0005 and 0.0096). However, there was no significant improvement during sodium chloride administration indicating that the effect of bicarbonate was the result of the correction of metabolic acidosis and not of the expansion of the extracellular volume.
对6名未接受透析的尿毒症患者进行了氮和钾平衡研究。每位患者在补充碳酸氢钠和氯化钠前后均接受了调查。研究的每个阶段持续时间超过1周。在整个研究过程中，每位患者的热量和蛋白质摄入量相同。通过尿素氮生成量与蛋白质摄入量的相关性来评估患者对饮食的依从性。补充碳酸氢钠期间，血尿素氮显著降低（p = 0.014），降低了36%，两项代谢平衡研究均有显著改善（p = 0.0005和0.0096）。然而，在给予氯化钠期间没有显著改善，这表明碳酸氢盐的作用是纠正代谢性酸中毒的结果，而不是细胞外液量扩充的结果。
