Parent D, Achten G, André J, Wiame L
Ann Dermatol Venereol. 1984;111(4):339-44.
We have treated 48 cases of onychomycosis (of which 37 were caused by dermatophytes, 10 by yeasts and one by Scopulariopsis brevicaulis) with 200 mg ketoconazole daily. We obtained recovery in 65 p. 100 of the cases of onyxis caused by dermatophytes and in 80 p. 100 of the cases of onychomycosis due to Candida. The one patient presenting an infection with Scopulariopsis brevicaulis recovered in 13 months. The average duration necessary to obtain complete recovery was 6 1/2 months for onychomycosis of the hands due to dermatophytes and 12 1/2 months for those of the feet. Perionyxis due to Candida needed 2 months of treatment with this drug, however 6 months of treatment were necessary to obtain recovery for onycholysis due to Candida. Biological tests remained normal and the side-effects were minimal and essentially gastrointestinal in our study. Ketoconazole is an effective treatment for onychomycosis: it is active against the different mycotic agents infecting nails and well tolerated by the patient. Several minor effects such as itching, nausea, headache and more serious reactions such as erythrodermia and hepatitis have been reported. Regular control and biological tests are therefore necessary. Patients with other diseases should avoid the use of ketoconazole for treatment of onychomycosis.
我们用每日200毫克酮康唑治疗了48例甲癣患者（其中37例由皮肤癣菌引起，10例由酵母菌引起，1例由短帚霉引起）。皮肤癣菌引起的甲癣患者中有65%康复，念珠菌引起的甲癣患者中有80%康复。那例感染短帚霉的患者在13个月后康复。皮肤癣菌引起的手部甲癣完全康复所需的平均时间为6个半月，足部甲癣则为12个半月。念珠菌引起的甲沟炎用该药治疗需要2个月，然而念珠菌引起的甲分离需要6个月的治疗才能康复。在我们的研究中，生物学检查结果保持正常，副作用极小，主要为胃肠道反应。酮康唑是治疗甲癣的有效药物：它对感染指甲的不同真菌病原体都有活性，且患者耐受性良好。曾有报道出现过一些轻微反应，如瘙痒、恶心、头痛，以及更严重的反应，如红皮病和肝炎。因此，需要定期进行检查和生物学检测。患有其他疾病的患者应避免使用酮康唑治疗甲癣。
