Cyclic AMP levels in peripheral blood lymphocytes of term pregnant women.

Alterations in cyclic AMP levels before and after trypsin treatment as compared with cyclic AMP levels of normal individuals are found in peripheral blood lymphocytes (PBL) of patients in which a defect in cell mediated immunity is suspected. Such conditions include pregnancy. It is concluded that low cyclic AMP levels in lymphocytes of pregnant women correlate with their clinical and immunological state and might partially explain the exception of pregnancy to the rule of allograft rejection.