急性颈上神经节切除术可抑制雄性大鼠去势后促性腺激素的升高。
Acute superior cervical ganglionectomy depresses the postcastration rise of gonadotropins in male rats.
作者信息
Chiocchio S R, Cardinali D P, Vacas M I, Tramezzani J H
出版信息
Brain Res. 1984 Sep 10;309(2):354-6. doi: 10.1016/0006-8993(84)90603-6.
In male rats, superior cervical ganglionectomy (SCGx) delayed the rise of serum FSH and LH induced by orchidectomy by 24 h. SCGx resulted in a decrease of median eminence norepinephrine (NE) content 16 h after surgery and in an increase of medio-basal hypothalamic cAMP synthesis and receptor occupancy. These data indicate that NE release from degenerating terminals originating in the superior cervical ganglion neurons modifies the regulatory mechanisms controlling the rise of gonadotropins after orchidectomy in rats.
在雄性大鼠中，双侧颈上神经节切除术（SCGx）使去势诱导的血清促卵泡激素（FSH）和促黄体生成素（LH）升高延迟了24小时。双侧颈上神经节切除术导致术后16小时正中隆起去甲肾上腺素（NE）含量降低，以及下丘脑基底部cAMP合成和受体占有率增加。这些数据表明，源自颈上神经节神经元的退化终末释放的去甲肾上腺素改变了大鼠去势后控制促性腺激素升高的调节机制。
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